Acetonitrile → HCID 178495306, compound

Participants

Reaction Steps

Combined 6-(4-(4-cyano-3-methylphenyl)-5-methoxy-1H-pyrazol-1-yl)-N-(3-methoxypropyl)nicotinamide (54.7 mg, 0.135 mmol) and lithium chloride (57.2 mg, 1.350 mmol) in DMA (2109 μl) and heated at 60° C. for 24 hours. The reaction mixture was then diluted with 0.6 mL DMSO and purified by preparative HPLC (35-60% acetonitrile in water under TFA conditions) and then again (15-40% acetonitrile in water under basic conditions) to give the title compound (14 mg, 0.036 mmol, 26.5%) as an off-white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.77 (quin, J=6.63 Hz, 2 H) 2.43 (s, 3 H) 3.25 (s, 3 H) 3.38-3.41 (m, 4 H) 7.08 (br. s., 2 H) 7.58 (d, J=8.08 Hz, 1 H) 7.88 (d, J=9.35 Hz, 1 H) 7.97 (s, 1 H) 8.29 (dd, J=8.46, 2.40 Hz, 1 H) 8.50 (d, J=8.34 Hz, 1 H) 8.61 (t, J=6.06 Hz, 1 H) 8.85 (d, J=1.77 Hz, 1 H); MS (M+H)+392.

Provenance & Evidence