Hydrazine, (phenylmethyl)-, hydrochloride (1:1) → 1-Benzyl-2-(1-methylsulfonyl-2-propylidene)hydrazine monohydrochloride
Reaction equation
[CH3:1][S:2]([CH2:5][C:6](=O)[CH3:7])(=[O:4])=[O:3].[ClH:9].[CH2:10]([NH:17][NH2:18])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CO>[ClH:9].[CH2:10]([NH:17][N:18]=[C:6]([CH3:7])[CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1Participants
Procedure
To a 50 ml volume three-necked flask, 1-methylsulfonyl-2-propanone (7-2-1) (2.01 g), methanol (10 ml) and benzylhydrazine monohydrochloride (14-c) (2.56 g) were added under a nitrogen atmosphere at room temperature, then additional methanol (10 ml) was added. The resulting reaction mixture was stirred at room temperature for three days, and filtered to give the primary crystal. The filtrate was concentrated under reduced pressure, and filtered again to give the crystal. The crystal was combined with the primary crystal to give 4.2 g of 1-benzyl-2-(1-methylsulfonyl-2-propylidene)hydrazine monohydrochloride (5-2-3). Additionally, the hydrochloride (5-2-3) (0.28 g) was dissolved in saturated aqueous sodium hydrogen carbonate solution (5.0 ml), and extracted with tert-butyl methyl ether (5.0 ml) 2 times. Then, the organic layer was concentrated under reduced pressure to give 0.22 g of 1-benzyl-2-(1-methylsulfonyl-2-propylidene)hydrazine (5-2-3′). NMR data of Compound (5-2-3′) is shown below.
Workup
- customThe resulting reaction mixture
- filtrationfiltered
- customto give the primary crystal
- concentrationThe filtrate was concentrated under reduced pressure
- filtrationfiltered again
- customto give the crystal
Sources & evidence
- ORD record
- ord-1c9f760c7b8744f6aac0a9cbbfe97638
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09040709B2
Reaction notes
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