Formaldehyde → HCID 66695576, compound

HRID 579296Notes

Reaction equation

HRID 579296 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][NH2:16])=[O:14])[CH3:2].[CH2:18]=O>CO>[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][N:16]=[CH2:18])=[O:14])[CH3:2]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 569428732-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide

Product 1

HCID 66695576HCID 66695576, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a 100 mL volume three-necked flask, 10.0 g of 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetohydrazide ((12-1)-(11)-39), 38 ml of methanol and 6.93 g of 37 wt % formalin aqueous solution were added and the mixture was stirred at room temperature for 5 hours. Methanol was added to the reaction mixture and cooled on ice-bath. The precipitated crystals were collected by filtration, washed with cool methanol, and dried under reduced pressure to give 1.22 g of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-methylidenehydrazine ((40-a)-(14)-1).

Workup

  1. temperaturecooled on ice-bath
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with cool methanol
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-a1ce3d5d43f54791a9863a27ee182484
Source dataset
uspto-grants-2015_05
Patent number
US09040709B2

Reaction notes

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