Hydrochloric Acid → HCID 86727195, compound

Participants

Reaction Steps

A solution of (3aR,6aS)-tert-butyl 5-(5-(2-chloro-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (10 mg, 0.021 mmol) in 1,4-dioxane (2 mL) was treated with 4M HCl in dioxane (1 mL) and stirred at room temperature for 3 h. The reaction mixture was concentrated in vacuo to give the title compound (2 mg, MS: 373.1 [M+H+], LCMS Rt=0.44 min (LCMS method D); 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.99 (br. s., 2H), 7.92 (d, J=8.59 Hz, 1H), 7.71 (d, J=2.02 Hz, 1H), 7.53-7.60 (m, 1H), 3.68 (dd, J=10.86, 7.83 Hz, 2H), 3.36 (dd, J=10.86, 3.28 Hz, 2H), 3.03-3.11 (m, 2H), 2.97-3.03 (m, 2H), 2.75 (dd, J=11.12, 3.03 Hz, 2H).

Provenance & Evidence