反应详情

To [2-fluoro-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-3-pyridyl]methanol (0.236 mmol; 79.5 mg) in dichloromethane (10 mL) was added DESS-MARTIN periodinane (0.355 mmol; 155 mg). The mixture as stirred at room temperature for 4 hours. The mixture was concentrated and the residue was purified on silica eluted with 0 to 100% EtOAc in DCM to afford 2-fluoro-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]pyridine-3-carbaldehyde as a pale yellow solid (69.7 mg, 88%).

1. concentrationThe mixture was concentrated
2. customthe residue was purified on silica
3. washeluted with 0 to 100% EtOAc in DCM