Dimethylamine → 1-(2-Chlorophenyl)-N,N-dimethylmethanamine

HRID 579420Notes

Reaction equation

HRID 579420 reaction equation
[CH3:1][NH:2][CH3:3].[Cl:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Cl>O>[Cl:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][N:2]([CH3:3])[CH3:1]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 119062-Chlorobenzyl chloride

Product 1

HCID 8180141-(2-Chlorophenyl)-N,N-dimethylmethanamine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The dimethylamine and water streams were initially combined and preheated to 130° C. The stream of o-chlorobenzyl chloride was then introduced by way of a mixing chamber. The temperature in the reaction tube was set to approximately 140° C. After running through the reaction zone, the mixture was cooled and depressurized. The workup analogous to example 1 afforded the (2-chlorobenzyl)dimethylamine target product with a yield and purity as in example 3.

Workup

  1. custompreheated to 130° C
  2. customwas set to approximately 140° C
  3. temperaturethe mixture was cooled

Sources & evidence

ORD record
ord-1ce7e88ae1444bdba8d0e8770aacc4b8
Source dataset
uspto-grants-2015_05
Patent number
US09040751B2

Reaction notes

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