Hydrochloric Acid → HCID 14231092, compound

Participants

Reaction Steps

A mixture of 1.0 g of 2-Chloro-4-amino-6,7-dimethoxyquinazoline, 1.28 g of 4-piperidone.HCl and 1.15 g of potassium carbonate in 50 ml of n-butanol was refluxed for 8 hours. and the solvent was removed under reduced pressure. To the residue was added 50 ml. of water and extracted with Ethyl acetate. Ethyl acetate extract was concentrated and the residue was washed with n-hexane. 0.98 g. of desired compound was obtained. mp. 228°~230° C. I.R. (KBr) 3350, 3200, 2900, 1700, 1645, 1595, 1570, 1500, 1465, 1260 cm-1 .

Provenance & Evidence