Hydrochloric Acid → HCID 178486953, compound

Participants

Reaction Steps

3.44 g of methyl 3-methoxy-2-oxocyclopentane-1-carboxylate [prepared as described in step (b) above] and 1.52 g of thiourea were dissolved in 20 ml of ethanol. A solution of 1.4 g of potassium hydroxide in 10 ml of water was then added to the resulting solution, and the mixture was heated under reflux for 3 hours, after which it was cooled to room temperature. 4 ml of concentrated aqueous hydrochloric acid were added to the mixture, and the crystals which precipitated were collected by filtration, washed with water and dried, to give 1.64 g of the title compound, melting above 250° C.

Provenance & Evidence