Ammonia → HCID 135583111, compound

HRID 579742Notes

Reaction equation

HRID 579742 reaction equation
S[C:2]1[NH:3][C:4](=[O:13])[C:5]2[CH2:10][CH2:9][CH:8]([O:11][CH3:12])[C:6]=2[N:7]=1.N>[Ni].O>[CH3:12][O:11][CH:8]1[C:6]2[N:7]=[CH:2][NH:3][C:4](=[O:13])[C:5]=2[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 178486953HCID 178486953, compound

Product 1

HCID 135583111HCID 135583111, compoundYield 83.1%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 962WaterSolvent

Procedure

1.58 g of 6,7-dihydro-2-mercapto-7-methoxy-3H,5H-cyclopenta[d]pyrimidin-4-one [prepared as described in step (c) above] and 4 g of Raney nickel were suspended in 15 ml of distilled water, and then 3 ml of concentrated aqueous ammonia were added to the resulting suspension. The mixture was then heated under reflux for 3 hours, after which time the resulting insoluble materials were filtered off from the hot reaction mixture. The filtrate was then evaporated under reduced pressure, to give 1.1 g of the title compound as colorless crystals.

Workup

  1. temperatureThe mixture was then heated
  2. temperatureunder reflux for 3 hours
  3. filtrationafter which time the resulting insoluble materials were filtered off from the hot reaction mixture
  4. customThe filtrate was then evaporated under reduced pressure

Sources & evidence

ORD record
ord-7151c5baf3ca4fa2bc518651f90b6fcf
Source dataset
uspto-grants-1988_06
Patent number
US04749704

Reaction notes

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