HCID 15029755, compound → HCID 14231165, compound

HRID 579775Notes

Reaction equation

HRID 579775 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)(O)[CH:10]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1>S(Cl)(Cl)=O>[CH3:32][O:31][C:28]1[CH:29]=[CH:30][C:25]([C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[C:10]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:11]2[CH:12]=[CH:13][C:14]([C:17]#[N:18])=[CH:15][CH:16]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 1

HCID 15029755HCID 15029755, compound

Product 1

HCID 14231165HCID 14231165, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

2,2-Bis-(4-methoxyphenyl)-2-hydroxy-1-(1-imidazolyl)-1-(4-cyanophenyl)-ethane (10.2 g) is dissolved in thionyl chloride (25 mL) and the solution is stirred at room temperature for 36 hours. The solvent is evaporated and the residue is chromatographed on silica gel (250 g). Elution with ethyl acetate affords the crystalline 2,2-bis-(4-methoxyphenyl)-1-(1-imidazolyl)-1-(4-cyanophenyl)-ethylene. The compound has m.p. 174°-176° after recrystallization from isopropanol.

Workup

  1. customThe solvent is evaporated
  2. customthe residue is chromatographed on silica gel (250 g)
  3. washElution with ethyl acetate

Sources & evidence

ORD record
ord-9d534f8ebe6d46c1be6bad05829f54a4
Source dataset
uspto-grants-1988_06
Patent number
US04749713

Reaction notes

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