HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-fluorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 1-Acetyl-4-(isothiocyanatomethyl)piperidine | HCID 15611590 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-fluorophenyl)thiourea | HCID 15611591 | 100% |
Reaction Steps
A mixture of 4 parts of 1-acetyl-4-(isothiocyanatomethyl)piperidine, 2.2 parts of 4-fluorobenzenamine and 90 parts of tetrahydrofuran was stirred overnight at reflux temperature. The reaction mixture was evaporated, yielding 6.2 parts (100%) of N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-fluorophenyl)thiourea as a residue (intermediate 12).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04749702 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-6ba11a5ef6d04607a33326e97ca1103c |
| Source note | uspto-grants-1988_06 |