反应详情

温度

140 °C

A mixture of 11 parts of 1-acetyl-4-piperidinemethanamine and 9 parts of 2-(methylthio)thiazolo[5,4-b]pyridine was stirred and heated for 20 hours at 140° C. The whole was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated, yielding 13.5 parts (93%) of 1-acetyl-N-(thiazolo[5,4-b]-pyridin-2-yl)-4-piperidinemethanamine as a residue (intermediate 51).

1. customThe whole was purified by column chromatography over silica gel using
2. additiona mixture of trichloromethane and methanol (95:5 by volume) as eluent
3. customThe pure fractions were collected
4. customthe eluent was evaporated