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Hydrogen Bromide → N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | 1-acetyl-N-(2-benzothiazolyl)-4-piperidinemethanamine | HCID 14048944 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide | HCID 14048948 | 79% |
反応手順
A mixture of 140 parts of 1-acetyl-N-(2-benzothiazolyl)-4-piperidinemethanamine and 1500 parts of a hydrobromic acid solution 24% in water was stirred and refluxed for 5 hours. The reaction mixture was evaporated and the residue was suspended in boiling ethanol. After cooling, the product was filtered off and dried, yielding 122 parts (79%) of N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide. hemihydrate; mp. >300° C. (intermediate 53).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04749702 |
| 出典データセット | uspto-grants-1988_06 |
| ORD ID | ord-b2f9f627d8aa4415a24a1e73021fb12d |
| 出典メモ | uspto-grants-1988_06 |