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HRID 579806作成日：2026年10月25日
Sodium Iodide → N-[[1-[3-[4-fluoro-2-(phenylmethoxy)phenoxy]propyl]-4-piperidinyl]methyl]-2-benzothiazolamine
https://huagongshe.com/reaction/579806
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide | HCID 14048948 | — |
| 反応物 | 1-(3-Chloropropoxy)-4-fluoro-2-(phenylmethoxy)benzene | HCID 21241619 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | N-[[1-[3-[4-fluoro-2-(phenylmethoxy)phenoxy]propyl]-4-piperidinyl]methyl]-2-benzothiazolamine | HCID 14048965 | 65.2% |
反応手順
A mixture of 3.2 parts of 1-(3-chloropropoxy)-4-fluoro-2-(phenylmethoxy)benzene, 4.1 parts of N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide, 6 parts of sodium carbonate, 0.1 parts of sodium iodide and 67.5 parts of N,N-dimethylacetamide was stirred overnight at 75° C. Water was added and the product was extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated. The oily residue was crystallized from acetonitrile. The product was filtered off and dried, yielding 3.3 parts (65.2%) of N-[[1-[3-[4-fluoro-2-(phenylmethoxy)phenoxy]propyl]-4-piperidinyl]methyl]-2-benzothiazolamine; mp. 129.5° C. (compound 24).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04749702 |
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| 出典データセット | uspto-grants-1988_06 |
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| ORD ID | ord-1017110c6c0d48d7a0011ca09e8eacd8 |
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| 出典メモ | uspto-grants-1988_06 |
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