Methanol → AC-Pro-ome

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A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 0.5 mmol of CH3OH, 6.5 mg of Co2 (CO)8, and 54.9 mg of N-acetyl-2-pyrroline. The reactor was pressurized with 1320 psi of CO and 300 psi of H2 at room temperature, and the reaction mixture ws stirred at 100° C. for 22 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 82.3% conversion of N-acetyl-2-pyrroline and 7.6% yield of N-acetylproline methyl ester.

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