Ammonia methanol → HCID 57286370, compound

HRID 579836Notes

Reaction equation

HRID 579836 reaction equation
[CH3:1][CH:2]([CH3:17])[CH2:3][C@H:4]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:5][CH:6]1[O:8][CH2:7]1.[NH3:18].CO>>[CH3:1][CH:2]([CH3:17])[CH2:3][C@H:4]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:5][CH:6]([OH:8])[CH2:7][NH2:18]

Participants

3

Reactant 2

HCID 21705897Ammonia methanolHCID 86742205HCID 86742205, compound

Product 1

HCID 57286370HCID 57286370, compound

Procedure

(S)-[3-Methyl-1-(2,3-epoxypropyl)butyl]carbamic acid, 1,1-dimethylethyl ester (3.6 g., 15.7 mmole) is added to a solution of saturated ammonia/methanol (100 ml.) and stirred for 36 hours at room temperature. The reaction mixture is concentrated into a solid residue of 3.8 g. of (1S)-[3-methyl-1-(3-amino-2-hydroxypropyl)butyl]carbamic acid, 1,1-dimethylethyl ester; m.p. (76°) 90-92°.

Workup

  1. concentrationThe reaction mixture is concentrated into a solid residue of 3.8 g
  2. customm.p. (76°) 90-92°

Sources & evidence

ORD record
ord-fe745187a8f740eababaa16a528f41cb
Source dataset
uspto-grants-1988_06
Patent number
US04749781

Reaction notes

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