Caffeic Acid → HCID 178485002, compound

HRID 579842Notes

Reaction equation

HRID 579842 reaction equation
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10]/[N:11]=[C:12](/[NH:15][C:16]#[N:17])\[NH:13][CH3:14].[C:18]([OH:30])(=[O:29])/[CH:19]=[CH:20]/[C:21]1[CH:28]=[CH:27][C:25]([OH:26])=[C:23]([OH:24])[CH:22]=1>ClCCl>[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10]/[N:11]=[C:12](/[NH:15][C:16]#[N:17])\[NH:13][CH3:14].[C:18]([O-:30])(=[O:29])/[CH:19]=[CH:20]/[C:21]1[CH:28]=[CH:27][C:25]([OH:26])=[C:23]([OH:24])[CH:22]=1

Participants

4

Reactant 2

HCID 689043Caffeic AcidHCID 178484997HCID 178484997, compound

Product 1

HCID 178485002HCID 178485002, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 1.26 g (0.5 cmole) cimetidine and 0.95 g (0.5 cmole) of caffeic acid (97%) were suspended in 12 ml of dichloromethane. The mixture was stirred for 2 hours at room temperature, followed by filtration and washing with dichloromethane. Dry weight: 2.17 g. Quantitative yield. M.p.: 126°-130° C. IR FIG. 1.

Workup

  1. filtrationfollowed by filtration
  2. washwashing with dichloromethane
  3. customDry weight

Sources & evidence

ORD record
ord-dd72b4ee876b42728596d6dd22be4057
Source dataset
uspto-grants-1988_06
Patent number
US04749790

Reaction notes

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