Ranisen → HCID 86742208, compound

HRID 579845Notes

Reaction equation

HRID 579845 reaction equation
[CH3:1][NH:2][C:3]([NH:8][CH2:9][CH2:10][S:11][CH2:12][C:13]1[O:17][C:16]([CH2:18][N:19]([CH3:21])[CH3:20])=[CH:15][CH:14]=1)=[CH:4][N+:5]([O-:7])=[O:6].[NH2:22][C@H:23]([C:28]([OH:30])=[O:29])[CH2:24][C:25]([OH:27])=[O:26]>ClCCl>[CH3:1][NH:2][C:3]([NH:8][CH2:9][CH2:10][S:11][CH2:12][C:13]1[O:17][C:16]([CH2:18][N:19]([CH3:20])[CH3:21])=[CH:15][CH:14]=1)=[CH:4][N+:5]([O-:7])=[O:6].[NH2:22][C@H:23]([C:28]([O-:30])=[O:29])[CH2:24][C:25]([O-:27])=[O:26]

Participants

4

Reactant 2

HCID 5039RanisenHCID 5960L-Aspartic Acid

Product 1

HCID 86742208HCID 86742208, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 1.57 g (0.5 cmole) of ranitidine and 0.66 g (0.5 cmole) of aspartic acid was suspended in 15 ml of dichloromethane. The mixture was stirred for 3 hours at room temperature, was filtered, washed with dichloromethane and dried. Weight: 2.16 g (yield 97%). M.p. 163°-166° C. IR FIG. 4.

Workup

  1. filtrationwas filtered
  2. washwashed with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-17c80faa65964bb79353e7823f4b5aa8
Source dataset
uspto-grants-1988_06
Patent number
US04749790

Reaction notes

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