HCID 178454156, compound → HCID 178454155, compound

Participants

Reaction Steps

A mixture of [N-(t-butyloxycarbonyl)-phenylalanine]-histidine-statine-alanine-statine-glutamic acid dibenzyl ester (90 mg., 0.077 mmoles), 20% Pd(OH)2/C catalyst(45 mg.) and methanol (10 ml.) was hydrogenated for 2 hours at room temperature and 50 psi H2. The reaction mixture was then filtered to remove the catalyst and the filtrate evaporated to yield a foam (72 mg.). This foam was triturated with ether and dried to yield a purified [N-(t-butyloxycarbonyl)-phenylalanine]-histidine-statine-glutamic acid foam (51 mg., 72% yield, 1H NMR, CDCl3, 1.5 delta, 9H s [BOC]).

Provenance & Evidence