Hydrochloric Acid → 3-[6-[6-(6-Methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]piperidin-4-ol

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Reaction Steps

To a solution of tert-butyl 4-hydroxy-3-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]piperidine-1-carboxylate (35 mg, 0.072 mmol) in 1,4-dioxane (2.00 mL, 23.4 mmol) was added hydrogen chloride (4 mol/L) in 1,4-dioxane (1.00 mL, 4.00 mmol). The reaction was stirred at RT 18 h. The reaction was concentrated and purified by reverse phase HPLC to yield 265. MS (ESI) m/z: 388.1.

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