HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → Pyrazolo(5,1-a)isoquinolin-5(6H)-one, 2-phenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Benzeneacetic acid, 2-(1,3-dioxo-3-phenylpropyl)- | HCID 184426 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Pyrazolo(5,1-a)isoquinolin-5(6H)-one, 2-phenyl- | HCID 184416 | 81.5% |
Reaction Steps
To ethanol (10 ml), there were added 2-(1,3-dioxo-3-phenylpropyl) phenylacetic acid (1.42 g) and hydrazine hydrate (0.25 g), followed by heating under reflux for 2 hours. Thereafter, the reaction mixture was cooled to give 2-phenyl-5,6-dihydropyrazolo-[5,1-a]isoquinolin-5-one (1.06 g). Mp. 181°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04751226 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-ce309ac7754b4e49a5beab5f8053156c |
| Source note | uspto-grants-1988_06 |