HRID57996
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 105 °C
PROCEDURE
实验过程
A mixture of tert-butyl 4-[6-[6-(6-chloropyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]piperazine-1-carboxylate (493 mg, 1 mmol), potassium vinyltrifluoroborate (335 mg, 2.500 mmol), 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride, DCM complex (55 mg, 0.07500 mmol) and triethylamine (0.63 ml, 4.500 mmol) in ethanol (9 mL) was degassed and heated in a sealed vial for 2 hours at 105° C. The mixture was left at room temperature for 20 hours. The precipitate was collected and washed with ethanol to give the crude material, 605 mg (99.8%). MS (ESI) m/z: 485.4 [M+H]+
WORKUP
后处理
- customwas degassed
- customThe precipitate was collected
- washwashed with ethanol