反应详情

To 5.24 g (26.0 mmol) of an approximately 3:1 mixture of the E and Z isomers of 1-bromo-6,6-dimethyl-2-hepten-4-yne was added sodium carbonate (5.52 g, 52.0 mmol) 80 ml of acetone and 170 ml of water. This mixture was heated to reflux for 3 hours. After cooling, most of the acetone was removed in vacuo and the mixture was extracted with ethyl ether three times. The combined ether layer was dried with sodium sulfate and concentrated to afford 3.97 of 6,6-dimethyl-2-hepten-4-yn-1-ol.

1. temperatureThis mixture was heated
2. temperatureto reflux for 3 hours
3. customwas removed in vacuo
4. extractionthe mixture was extracted with ethyl ether three times
5. dry with materialThe combined ether layer was dried with sodium sulfate
6. concentrationconcentrated