7-iodo-1H-indazol-3-amine → N~1~,N~1~-Diethyl-N~3~-(7-iodo-1H-indazol-3-yl)propane-1,3-diamine

HRID 580142Notes

Reaction equation

HRID 580142 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14](I)[CH:15]=2)[NH:10][N:9]=1)[CH3:2].NC1C2C(=C([I:30])C=CC=2)NN=1>>[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[C:16]2[C:11](=[C:12]([I:30])[CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 201358107-iodo-1H-indazol-3-amineHCID 20135848N~1~,N~1~-Diethyl-N~3~-(5-iodo-1H-indazol-3-yl)propane-1,3-diamine

Product 1

HCID 20135861N~1~,N~1~-Diethyl-N~3~-(7-iodo-1H-indazol-3-yl)propane-1,3-diamineYield 54%

Procedure

The same procedures for preparing 3-(3-diethylaminopropylamino)-5-iodoindazole as described in Example 71 were repeated except that 3-amino-7-iodoindazole was employed instead of the 3-amino-5-iodoindazole. As a result, 7.57 g of 3-(3-diethylaminopropylamino)-7-iodoindazole having the following analytical values was obtained in a yield of 54%.

Sources & evidence

ORD record
ord-b51f55c9397f4df394825d43db58600d
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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