3-Amino-4-chloroindazole → 1-(3-Piperidinopropyl)-3-amino-5-chloroindazole

HRID 580154Notes

Reaction equation

HRID 580154 reaction equation
C(N(CC)CCCN1C2C(=C(Cl)C=CC=2)C(N)=N1)C.Br.Br[CH2:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1.[NH2:31][C:32]1[C:40]2[C:35](=[CH:36][CH:37]=[C:38]([Cl:41])[CH:39]=2)[NH:34][N:33]=1.Br.BrCCCN(CC)CC.NC1C2C(=CC=CC=2Cl)NN=1>>[N:25]1([CH2:24][CH2:23][CH2:22][N:34]2[C:35]3[C:40](=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=3)[C:32]([NH2:31])=[N:33]2)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

6

Reactant 5

HCID 3134443-Amino-4-chloroindazoleHCID 12639158(3-Bromopropyl)diethylamine hydrobromideHCID 132293251-(3-Diethylaminopropyl)-3-amino-4-chloroindazoleHCID 201357721-(3-Bromopropyl)piperidine HydrobromideHCID 215161643-Amino-5-chloro-1h-indazole

Product 1

HCID 201357951-(3-Piperidinopropyl)-3-amino-5-chloroindazole

Procedure

The same procedures for preparing 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole as described in Example 89 were repeated except that 3-bromopropylpiperidine hydrobromide and 3-amino-5-chloroindazole were employed instead of the 3-bromopropyldiethylamine hydrobromide and the 3-amino-4-chloroindazole, respectively. As a result, 1-(3-piperidinopropyl)-3-amino-5-chloroindazole was obtained.

Sources & evidence

ORD record
ord-008a6e5f787548d3bac102f0339a63ab
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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