1-(3-Piperidinopropyl)-3-amino-5-chloroindazole → 1-(3-Piperidinobutyl)-3-amino-5-chloroindazole

HRID 580157Notes

Reaction equation

HRID 580157 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=3)[C:12]([NH2:20])=[N:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:21]C(N1CCCCC1)CCBr>>[N:1]1([CH:7]([CH3:21])[CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=3)[C:12]([NH2:20])=[N:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 201357951-(3-Piperidinopropyl)-3-amino-5-chloroindazoleHCID 201358621-(4-Bromobutan-2-yl)piperidine

Product 1

HCID 201357551-(3-Piperidinobutyl)-3-amino-5-chloroindazole

Procedure

The same procedures for preparing 1-(3-piperidinopropyl)-3-amino-5-chloroindazole as described in Example 100 were repeated except that 1-(1-methyl-3-bromopropyl)piperidine was employed instead of the 3-bromopropylpiperidine. As a result, 1-(3-piperidinobutyl)-3-amino-5-chloroindazole was obtained.

Sources & evidence

ORD record
ord-97ea396843cf4bd4b3fbe7c84ea7898a
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

Loading…