3-Amino-4-chloroindazole → 1-(3-Dimethylaminobutyl)-3-amino-5-chloroindazole

HRID 580159Notes

Reaction equation

HRID 580159 reaction equation
C(N(CC)CC[CH2:6][N:7]1[C:15]2[C:10](=[C:11](Cl)C=C[CH:14]=2)C(N)=N1)C.[NH2:20][C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([Cl:30])[CH:28]=2)[NH:23][N:22]=1.Br.Br[CH2:33]CCN(CC)CC.NC1C2C(=CC=CC=2Cl)NN=1>>[CH3:33][N:7]([CH3:6])[CH:15]([CH3:14])[CH2:10][CH2:11][N:23]1[C:24]2[C:29](=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[C:21]([NH2:20])=[N:22]1

Participants

5

Reactant 4

HCID 3134443-Amino-4-chloroindazoleHCID 12639158(3-Bromopropyl)diethylamine hydrobromideHCID 132293251-(3-Diethylaminopropyl)-3-amino-4-chloroindazoleHCID 215161643-Amino-5-chloro-1h-indazole

Product 1

HCID 201357981-(3-Dimethylaminobutyl)-3-amino-5-chloroindazole

Procedure

The same procedures for preparing 1-(3-diethylaminopropyl)-3-amino-4-chloroindazole as described in Example 89 were repeated except that 1-(1-methyl-3-bromopropyl)-dimethylamine hydrobromide and 3-amino-5-chloroindazole were employed instead of the 3-bromopropyldiethylamine hydrobromide and the 3-amino-4-chloroindazole, respectively. As a result, 1-(3-dimethylaminobutyl)-3-amino-5-chloroindazole was obtained.

Sources & evidence

ORD record
ord-e2861580ddd446be84099dd2b72213b5
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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