HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione → 1-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione | HCID 2755857 | — |
| Reactant | (3-Bromopropyl)diethylamine hydrobromide | HCID 12639158 | — |
| Reactant | 2-(4-chloro-1H-indazol-3-yl)isoindoline-1,3-dione | HCID 13229771 | — |
| Reactant | 4-(3-Bromopropyl)morpholine hydrobromide | HCID 21509538 | — |
| Product | 1-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)indazole | HCID 13210572 | — |
Reaction Steps
The same procedures as described in Example 89 were repeated except that 8.0 g of 3-phthalimido-indazole and 10.1 g of 3-bromopropylmorpholine hydrobromide were employed instead of the 3-phthalimido-4-chloroindazole and the 4.83 g of 3-bromopropyldiethylamine hydrobromide, respectively. As a result, 8.7 g of 1-(3-morpholinopropyl)-3-(3-diethylaminopropylamino)indazole was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04751302 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-596f0c7f9ca342e5af05dd92d1f6b698 |
| Source note | uspto-grants-1988_06 |