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HRID58021

反应详情

EQUATION

反应方程式

HRID 58021 的结构方程式

REACTANTS

反应物

3
结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

结构：CC(=O)OCC(=O)[C@@]1(C)[C@H](C)CC2C3CCC4=CC(=O)CC[C@]4(C)C3=CC[C@@]21C
HCID59271735

未命名化合物

结构：CC1CC2C3CCC4=CC(=O)CCC4(C)C3=CCC2(C)C1(C)C(=O)CO
HCID72266819

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1CC2C3CCC4=CC(=O)CC[C@]4(C)C3=CC[C@]2(C)[C@@]1(C)C(=O)CO
HCID59271745

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

10S,13S,16R,17S)-17-(2-hydroxyacetyl)-10,13,16,17-tetramethyl-6,7,8,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one: 2-oxo-2-((10S,13S,16R,17S)-10,13,16,17-tetramethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl acetate (144 g) is stirred in 1500 ml methanol and treated with sodium methoxide (25%, 5 ml) for 30 minutes. The mixture is partitioned between methylene chloride and sodium bicarbonate. The organic phase is separated and washed with sodium bicarbonate, dried over sodium sulfate, and concentrated to give the title compound.

WORKUP

后处理

  1. customThe mixture is partitioned between methylene chloride and sodium bicarbonate
  2. customThe organic phase is separated
  3. washwashed with sodium bicarbonate
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated