Sodium Hydroxide → HCID 86742228, compound

Participants

Reaction Steps

A solution of 500 mg (1.34 mmoles) of methyl 2-(5-t-butoxycarbonylamino-1,2,4-thiadiazol-3-yl)-2-cyclopentyloxyiminoacetate and 2N NaOH solution (2 ml, 4 mmoles) in 15 ml of CH3OH was refluxed for 30 minutes. The reaction mixture was evaporated and 10 ml of ethyl acetate-H2O (1:1) was added to the solution. The water layer was separated, acidified to pH 2 with 6N HCl and extracted with ethyl acetate (10 ml×2). The organic layer was washed with brine, dried over MgSO4 and concentrated under reduced pressure to give 377 mg (78%) of the title compound. Mp. 185° C. (dec.).

Provenance & Evidence