Dimethylformamide → HCID 13798269, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2,4-dichloro-5-hydroxyphenyl)-3,4,5-trimethylpyrazole (27.1 g), isopropyl bromide (12.3 g), aqueous sodium hydroxide (4.2 g) and dimethylformamide (150 ml) was stirred at 70° C. for 2 hours. To the reaction mixture, after cooling, were added water and toluene, to form two layers. The toluene layer as separated was washed with water and then dried over anhydrous sodium sulfate. Removal of the toluene by distillation in vacuo gave the titled compound (27.9 g) as a pale yellow oil, which was then purified through silica gel column chromatography to afford a white crystalline solid. m.p. 56°-58° C.

Provenance & Evidence