HCID 131736965, compound → HCID 131736966, compound

HRID 58029Notes

Reaction equation

HRID 58029 reaction equation
C([O:8][C:9](=[O:31])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:30])[CH:16]([CH:26]([CH2:28][CH3:29])[CH3:27])[NH:17][C:18](=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)C1C=CC=CC=1.[H][H]>CO.[C].[Pd]>[C:18]([NH:17][CH:16]([C:15]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:10]1[C:9]([OH:31])=[O:8])=[O:30])[CH:26]([CH2:28][CH3:29])[CH3:27])(=[O:25])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 2

HCID 131736965HCID 131736965, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131736966HCID 131736966, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

N-benzoyl-D,L-isoleucyl-L-proline benzyl ester (1.1 g) was dissolved in methanol (15 ml), and 10% palladium-carbon (120 mg) was added. The resulting mixture aerated with hydrogen was allowed to react at room temperature for 3 h, filtered and concentrated under reduced pressure to remove the solvent to give a colourless sticky matter (1.04 g, 99%), which was directly used for the next reaction.

Workup

  1. customto react at room temperature for 3 h
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure
  4. customto remove the solvent
  5. customto give a colourless sticky matter (1.04 g, 99%), which
  6. customwas directly used for the next reaction

Sources & evidence

ORD record
ord-ac1b199782ed4f6dae806d53f049f69a
Source dataset
uspto-grants-2016_09
Patent number
US09434760B2

Reaction notes

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