HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → N-(5-bromo-6-methylpyridin-2-yl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Pyridinamine, 5-bromo-6-methyl- | HCID 170678 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-bromo-6-methylpyridin-2-yl)methanesulfonamide | HCID 79049128 | — |
Reaction Steps
To a mixture of 5-bromo-6-methylpyridin-2-amine (0.3 g, 1.604 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.559 mL, 3.21 mmol) in DCM (10 mL) was added methanesulfonyl chloride (0.137 mL, 1.764 mmol) at 0° C. The reaction mixture was stirred at room temperature for 48 hours and was subsequently concentrated in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434743B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-eff90a1b5e1d49ba85eea4a95d9dbafd |
| Source note | uspto-grants-2016_09 |