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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 580438Generated: October 30, 2026

8-Amino-2-naphthalenol → n-(7-Hydroxynaphthalen-1-yl)formamide

https://huagongshe.com/reaction/580438

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-Amino-2-naphthalenolHCID 8358—
ReactantAcetic anhydride formic acidHCID 19869020—
Productn-(7-Hydroxynaphthalen-1-yl)formamideHCID 244439—

Reaction Conditions

Temperature50 °C

Reaction Steps

Ten grams of 8-amino-2-naphthol were added to a mixture of acetic anhydride/formic acid (40 mL:20 mL). The mixture was warmed at 50° C. for one hour and then quenched on ice. After stirring for some time, the product solidified and was filtered off. Recrystallization from ethanol gave 6 g of 8-formamido-2-naphthol melting at 203°-205° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04753922
Source datasetuspto-grants-1988_06
ORD IDord-402682e39859488ca790276b1fbdf26b
Source noteuspto-grants-1988_06