Pyrrolidine → HCID 13558051, compound

Participants

Reaction Steps

3.3 g of 1-dimethylamino-7-chloro-6-fluoro-8-nitro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are reacted with 6 g of pyrrolidine analogously to Example 11 and, after acidification to pH 1 with 10% strength hydrochloric acid, 3.4 g of 1-dimethylamino-6-fluoro-8-nitro-7-(1-pyrrolidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are isolated. After recrystallization from glycol monomethyl ether, the crystals have a melting point of 266°-268° C., with decomposition.

Provenance & Evidence