HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzoic Acid → 4-((Ethoxycarbonyl)amino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzoic Acid | HCID 978 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-((Ethoxycarbonyl)amino)benzoic acid | HCID 610598 | — |
Reaction Conditions
| Temperature | 5 °C |
|---|
Reaction Steps
A mixture composed of 4-aminobenzoic acid (10 g), 1N aqueous sodium bicarbonate solution (365 cc) and ethyl chloroformate (7 cc) is left stirring for 30 minutes at 5° C. 2.5N hydrochloric acid (150 cc) is then added to the reaction mixture. The precipitate formed is separated by filtration, washed with water (3×200 cc) and dried at 40° C. under reduced pressure (0.07 kPa). 4-(Ethoxycarbonylamino)benzoic acid (13.8 g), m.p. 207° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04753933 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-eb0c8ab7bbf14c9f8cba2a832c5e7c15 |
| Source note | uspto-grants-1988_06 |