反应详情

A mixture of 1.39 g of imidazole-4-butanamine, 1.98 g of 4-chloroisatoic anhydride and 25 ml of ethanol was left at room temperature for 20 hours and concentrated. The residue and 5 ml of triethyl orthoformate were heated in an oil bath at 100°-125° C. for 3 hours and concentrated. The mixture was treated with ether to obtain the desired product, mp 123°-125° C.

1. concentrationconcentrated
2. temperatureThe residue and 5 ml of triethyl orthoformate were heated in an oil bath at 100°-125° C. for 3 hours
3. concentrationconcentrated
4. additionThe mixture was treated with ether