Ethyl orthoformate → HCID 20134059, compound

HRID 580476Notes

Reaction equation

HRID 580476 reaction equation
[NH2:1][C:2]1[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][CH:8]([CH3:15])[CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1)=[O:5].[CH:23](OCC)(OCC)OCC>>[N:10]1([CH2:9][CH:8]([CH3:15])[CH2:7][N:6]2[C:4](=[O:5])[C:3]3[C:2](=[CH:19][CH:18]=[C:17]([N+:20]([O-:22])=[O:21])[CH:16]=3)[N:1]=[CH:23]2)[CH:14]=[CH:13][N:12]=[CH:11]1

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 14011172HCID 14011172, compound

Product 1

HCID 20134059HCID 20134059, compound

Procedure

A mixture of 3.03 g of 2-amino-N-[3-(1H-imidazol-1-yl)-2-methylpropyl]-5-nitrobenzamide and 10 ml of triethyl orthoformate is heated at reflux temperature for 20 hours and concentrated to obtain the above compound.

Workup

  1. temperatureis heated
  2. temperatureat reflux temperature for 20 hours
  3. concentrationconcentrated
  4. customto obtain the above compound

Sources & evidence

ORD record
ord-7ac8628154834ef9848cb75056f1a819
Source dataset
uspto-grants-1988_06
Patent number
US04753944

Reaction notes

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