2-Chlorobenzoic Acid → HCID 13983392, compound

Participants

Reaction Conditions

Reaction Steps

N,N'-Carbonyldiimidazole (12.9 g) is added to a solution of 2-chlorobenzoic acid (12.5 g) in anhydrous tetrahydrofuran (250 cc). The mixture is stirred for 2 hours at a temperature in the region of 20° C., until the evolution of gas has ceased. 2-Amino-7-chloro-1,8-naphthyridine (8.9 g) is then added and the mixture is heated under reflux for 22 hours. The reaction mixture is poured into distilled water (2000 cc), and the precipitate formed is separated by filtration, washed with water and dried in the air. On recrystallization from ethanol (180 cc) of the product thereby obtained, N-(7-chloro-1,8-naphthyridin-2-yl)-2-chlorobenzamide (6.9 g), m.p. 180° C., is obtained.

Provenance & Evidence