Veratric Acid → HCID 13983398, compound

Participants

Reaction Steps

The procedure is similar to that described in Example 2, but starting with 3,4-dimethoxybenzoic acid (14.6 g), N,N'-carbonyldiimidazole (12.9 g) and 2-amino-7-chloro-1,8-naphthyridine (8.9 g), and heating for 17 hours under reflux. The product obtained, after precipitation of the reaction mixture in water (1000 cc) and drying, is purified by recrystallization in acetonitrile (250 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-3,4-dimethoxybenzamide (8.5 g), m.p. 196° C., is thereby obtained.

Provenance & Evidence