Isonicotinic Acid → HCID 13983401, compound

Participants

Reaction Steps

The procedure is similar to that described in Example 2, but starting with 4-pyridinecarboxylic acid (6.2 g), N,N'-carbonyldiimidazole (8.1 g) and 2-amino-7-chloro-1,8-naphthyridine (9 g). The product obtained, after precipitation in water (500 cc), washing with tetrahydrofuran (50 cc), then washing with water (200 cc) and drying (9.8 g; m.p. approximately 220° C.), is purified by crystallization in acetonitrile (850 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-4-pyridinecarboxamide (5.2 g), m.p. 228° C., is thereby obtained.

Provenance & Evidence