2-Pyrazinecarboxylic acid → HCID 13983402, compound

Participants

Reaction Conditions

Reaction Steps

The procedure is similar to that described in Example 1, but starting with 2-pyrazinecarboxylic acid (7.5 g), N,N'-carbonyldiimidazole (9.7 g) and 2-amino-7-chloro-1,8-naphthyridine (10.8 g). The insoluble product is separated by filtration, washed with tetrahydrofuran (3×50 cc) and then with water (300 cc) and dried in the air. The product is suspended in acetonitrile (100 cc), stirred for 1 hour at 25° C. and separated by filtration, and then dried at 50° C. under reduced pressure (0.07 kPa). N-(7-Chloro-1,8-naphthyridin-2-yl)-2-pyrazinecarboxamide (11.75 g), m.p. 308° C., is thereby obtained.

Provenance & Evidence