Thionyl Chloride → 5,6-Dihydro-1,4-dithiin-2-carbonyl chloride

Participants

Reaction Steps

A suspension of 5,6-dihydro-1,4-dithiin-2-carboxylic acid (13.1 g) in thionyl chloride (60 cc) is gradually heated to reflux. After 30 minutes under reflux, the solution obtained is concentrated to dryness at 50° C. under reduced pressure (4 kPa) and the oily residue obtained is washed with cyclohexane (2×100 cc). The decanted oil is dried at 50° C. under reduced pressure (4 kPa). 5,6-Dihydro-1,4-dithiin-2-carbonyl chloride (15.8 g) is thereby obtained, and this is used as it is in the following operation.

Provenance & Evidence