反应详情

The procedure is similar to that described in Example 2, but starting with 5,6-dihydro-1,4-dithiin-2-carboxylic acid (10.9 g), N,N'-carbonyldiimidazole (10.9 g) and 2-amino-7-phenoxy-1,8-naphthyridine (11.9 g), and heating for 18 hours under reflux. The product obtained, after precipitation in water, washing with water and drying (18 g; m.p. approximately 240° C.), is purified by recrystallization in dimethylformamide (150 cc). N-(7-Phenoxy-1,8-naphthyridin-2-yl)-5,6-dihydro-1,4-dithiin-2carboxamide (15 g), m.p. 245° C., is thereby obtained.

1. temperatureheating for 18 hours
2. temperatureunder reflux
3. customThe product obtained
4. customafter precipitation in water
5. washwashing with water
6. customdrying (18 g; m.p. approximately 240° C.)
7. customis purified by recrystallization in dimethylformamide (150 cc)