HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-1,8-naphthyridin-2-amine → HCID 13983405, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| Reactant | 1,4-Oxathiin-2-carboxylicacid, 5,6-dihydro- | HCID 6423262 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13983405 | HCID 13983405 | 47.8% |
Reaction Steps
The procedure is similar to that described in Example 2, but starting with 5,6-dihydro-1,4-oxathiin-2-carboxylic acid (7.3 g), N,N'-carbonyldiimidazole (9.7 g) and 2-amino-7-chloro-1,8-naphthyridine (7.2 g). The product obtained by precipitation in water is purified by recrystallization in dimethylformamide (60 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-5,6-dihydro-1,4-oxathiin-2-carboxamide (5.9 g), m.p. 270° C., is thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04753941 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-bb6dbf27525b4ccdb7681ca6268312fb |
| Source note | uspto-grants-1988_06 |