HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-1,8-naphthyridin-2-amine → HCID 13983409, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| Reactant | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13983409 | HCID 13983409 | 57.5% |
Reaction Steps
The procedure is similar to that described in Example 2, but starting with 5-chloro-2-thiophenecarboxylic acid (9.5 g), N,N'-carbonyldiimidazole (9.5 g) and 2-amino-7-chloro-1,8-naphthyridine (8 g). The product obtained by precipitation in water is purified by recrystallization in propanol (700 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-5-chloro-2-thiophenecarboxamide (8.3 g), m.p. 275° C., is thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04753941 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-db660284ac2b4ac3afb07fe65b632893 |
| Source note | uspto-grants-1988_06 |