HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-1,8-naphthyridin-2-amine → HCID 13983410, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| Reactant | 5-(Methylsulfanyl)thiophene-2-carboxylic acid | HCID 714372 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13983410 | HCID 13983410 | 75.9% |
Reaction Steps
The procedure is similar to that described in Example 2, but starting with 5-methylthio-2-thiophenecarboxylic acid (5.6 g), N,N'-carbonyldiimidazole (5.2 g) and 2-amino-7-chloro-1,8-naphthyridine (4.3 g). The product obtained by precipitation in water is purified by recrystallization in a dimethylformamide/methanol (5:5 by volume) mixture (200 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-5-methylthio-2-thiophenecarboxamide (6.1 g), m.p. 235° C., is thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04753941 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-fd455909f4524232bef5786761e2f1e1 |
| Source note | uspto-grants-1988_06 |