5-Bromo-2-furanecarboxylic acid → HCID 13983411, compound

Participants

Reaction Steps

The procedure is similar to that described in Example 2, but starting with 5-bromo-2-furancarboxylic acid (2.9 g), N,N'-carbonyldiimidazole (2.4 g) and 2-amino-7-chloro-1,8-naphthyridine (1.8 g). The product obtained by precipitation in water is purified by recrystallization in a dimethylformamide/methanol (5:5 by volume) mixture (100 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-5-bromo-2-furancarboxamide (2.6 g), m.p. 285° C., is thereby obtained.

Provenance & Evidence