6-Methoxypyridazine-3-carboxylic acid → N-(7-Phenoxy-1,8-naphthyridin-2-yl)-6-methoxy-3-pyridazinecarboxamide

Participants

Reaction Steps

The procedure is similar to that described in Example 2, but starting with 6-methoxy-3-pyridazinecarboxylic acid (2.2 g), N,N'-carbonyldiimidazole (2.3 g) and 2-amino-7-phenoxy-1,8-naphthyridine (2.7 g). The product obtained by precipitation in water is purified by recrystallization in acetonitrile (300 cc). N-(7-Phenoxy-1,8-naphthyridin-2-yl)-6-methoxy-3-pyridazinecarboxamide (3 g), m.p. 95° C., is thereby obtained.

Provenance & Evidence