Water → 2-(3-Nitrophenylmethylidene)-3-oxobutanoic acid, 1-methylpropyl ester

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Reaction Steps

A solution of sec-butyl acetoacetate (5.0 g, 0.031 moles), 3-nitrobenzaldehyde (4.7 g, 0.031 moles), 0.5 ml of piperidine and 0.5 ml of acetic acid in 50 ml of benzene was heated at reflux for one hour collecting 1 eq. of water. The cooled solution, in ethyl acetate, was washed with sodium hydrogen carbonate, potassium hydrogen sulfate and brine, dried and evaporated to give 9.2 g of the title A compound as a dark oil.

Provenance & Evidence